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刘晓红

发布时间:2017-04-07 点击量:

姓名:刘晓红

性别:女

籍贯:辽宁

联系电话:024-23986325

E-Mail:1204709672@qq.com

职称/职务:副教授

通讯地址:沈阳市沈河区文化路103号

邮政编码:110016

学习/工作经历:

1996——2000年金沙6165总站线路检测药物分析专业本科阶段学习

2000——2007年金沙6165总站线路检测药剂学专业研究生阶段学习

2005年至今金沙6165总站线路检测教师

兼职情况:

科研/获奖情况:

1.建立预测中药有效单体与绿茶提取物发生药物相互作用的分子药动学模型,国家自然科学基金青年科学基金项目,基金编号30901996(负责人)

2.基于OCTN2和白蛋白转运载体序列靶向的吉西他滨口服前药的研究,金沙6165总站线路检测专项科研基金(负责人)

3.新释药系统关键技术及新产品产业化研究——美洛昔康二乙胺贴临床前研究,国家科技重大专项(参与)

4.肿瘤胞外pH微环境响应的去PEG化“配体包埋式”主动靶向透明质酸环糊精纳米粒的几个科学问题,国家自然科学基金青年科学基金项目,基金编号81573371(参与)

5.纳米结晶吸收机制的研究及其在设计、评价新型纳米结晶中的应用,国家自然科学基金青年科学基金项目,基金编号81173008(参与)

6.靶向肠道上皮细胞顶侧OCTN2转运体口服高效纳米粒的构建及其对OCTN2活性调控的研究,国家自然科学基金青年科学基金项目,基金编号81473164(参与)

7.PEPT1和VACVase双靶向地西他滨口服前药的设计与评价,国家自然科学基金青年科学基金项目,基金编号81302722(参与)

8.具有粘液层渗透及P-gp抑制双重作用新型口服高效纳米混合胶束的构建和评价,国家自然科学基金青年科学基金项目,基金编号81503020(参与)

9.固定剂量复方抗结核药物,2011年,辽宁省科技进步一等奖(排名第11)

10.结合固体分散/微粉化技术制备高生物利用度的尼莫地平渗透泵型控释片,2014年,辽宁省自然科学学术成果奖三等(排名第一)

教学/指导研究生情况:

发表论文/出版著作:

1.Xiaohong Liu, Shang Wang, Liqing Chaia, Dong Zhang, Yinghua Sun,Lu Xu*, Jin Sun*. A two-step strategy to design high bioavailable controlled-release nimodipine tablets: The push-pull osmotic pump in combination with the micronization/solid dispersion technique. Int J Pharm, 2014, 461: 529-539. (IF=3.650)

2.Yan Liu, Xiao Luo, Xiaochao Xu, Nannan Gao, Xiaohong Liu*. Preparation, characterization and in vivo pharmacokinetic study of PVP-modified oleanolic acid liposomes. Int J Pharm, 2017, 517: 1-7.(IF=3.994)

3.Qikun Jiang, Wanjun Liu, Xiaoting Li, Tianhong Zhang, Yongjun Wang, Xiaohong Liu*. Detection of related substances in polyene phosphatidyl choline extracted from soybean and in its commercial capsule by comprehensive supercritical fluid chromatography with mass spectrometry compared with high-performance liquid chromatography with evaporative light scattering detection. J SEP SCI, 2016, 39:350-7.(IF=2.741)

4.Meina Liu, Qiuyang Yu, Ping Li, Meng Zhu, Mingming Fang, Bingjun Sun,Mengchi Sun, Yinghua Sun, Peng Zhang, Zhonggui He, Jin Sun, Yongjun Wang,Xiaohong Liu*. Simultaneous determination of parecoxib sodium and its activemetabolite valdecoxib in rat plasma by UPLC–MS/MS and itsapplication to a pharmacokinetic study after intravenous andintramuscular administration. J Chromatogr B Analyt Technol Biomed Life Sci, 2016, 1022: 220-229. (IF=2.687)

5.Xudan Wei, Ping Li, Meina Liu, Yuqian Du, Menglin Wang, Jinling Zhang, Jing Wang, Hongzhuo Liu, Xiaohong Liu*. Absolute oral bioavailability of fenofibric acid and choline fenofibrate in rats determined by ultra-performance liquid chromatography tandem mass spectrometry. Biomed Chromatogr., 2017, 31(4). (IF=1.729)

6.Xinhuan Wan, He Wang, Panqin Ma, Long Xi, Jin Sun, Zhonggui He, Xiangrong Zhang*, Xiaohong Liu*. Simultaneous determination of oxiracetam and its degradedsubstance in rat plasma by HPLC-MS/MS and its application topharmacokinetic study after a single high-dose intravenousadministration. J Chromatogr B Analyt Technol Biomed Life Sci, 2014, 15: 95-100. (IF=2.729)

7.Qi. Zhang, Jin Sun, Tianshu Lu, Jinling Zhang, Chunnuan Wu, Lin Li, Zhonggui He, Yanfang Zhao*, Xiaohong Liua*. A rapid and sensitive LC-MS/MS method for evaluation of the absolute oral bioavailability of a novel c-Met tyrosine kinase inhibitor QBH-196 in rats. Biomed Chromatogr., 2015, 29: 1650-6. (IF=1.72)

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